Robert Lufkin MD

"My toilet saved my life." That is the sentence Throne Sciences CEO Scott Hickle wants Americans to be able to say a decade from now. (1/7)

In US healthcare, "normal" lab values can quietly mean sick. (1/8)

Many people assume evolution only favors survival until reproduction. Growing evidence challenges that idea. (1/6)

The lie I taught in medical school: sleep is for muscle repair. The 2011 JAMA study most people have never heard of: 5 hours of sleep for ONE week dropped daily testosterone 10-15% in healthy young men -- the hormonal equivalent of aging 10-15 years in 7 nights. (1/5)

Jeanne Calment died at 122. No one has lived longer. That's not a record waiting to be broken -- it's the biological ceiling we've been hitting for a century. (1/4)

The FDA just approved a longevity drug -- and almost nobody noticed. Anktiva (an IL-15 superagonist) was greenlit for bladder cancer. But the scientist behind it, Patrick Soon-Shiong, calls it the most important longevity drug of the decade. (1/5)

Even if just 10% of what longevity scientists are claiming is true, we are living through one of the most consequential scientific revolutions of our lifetime. (1/8)

I was taught that a glass of red wine a day is good for your heart. Then a new study with 4.8M patients just looked at it. A 2023 JAMA Network Open meta-analysis — 107 studies, 4.8M people. (1/3)

Want more IL-15 and NK cells while you are waiting for ANKTIVA? Lift weights. The strongest natural stimulus for IL-15 isn'''t a supplement or peptide — it'''s resistance training. Your muscles are an endocrine organ pumping out longevity signals that activate your NK cells. 🎙 youtu.be/220KHIdFCwg

A Green Beret veteran told an Army Ranger retreat guide: "I haven't been able to hug my son in 10 years. I freeze every time." One psilocybin journey later — his son walked up. The dad opened his arms. (1/6)

Copernicus worked on his masterpiece, De revolutionibus, until his death at age 70. It is not that people in the past did not live to old age - many did. Rather, high infant mortality pulled the average life expectancy down. This is a point many people still misunderstand. (1/5)

A Harvard-trained Army Ranger described psilocybin to me like this: "Your brain is a snowy mountain. Every thought is a sled track. After 40 years you are riding the same five grooves down the same hill." "Psilocybin is fresh snow." (1/2)

One molecule. Four hallmarks of aging. IL-15 is a cytokine your body already makes - and emerging research shows it hits 4 of the 12 aging hallmarks at once: immune decline, chronic inflammation, mitochondrial dysfunction, and cellular senescence. (1/7)

Forever Young - our new longevity movie - just dropped on Apple TV. I had the privilege of joining a remarkable group of scientists, physicians, and patients to explore one of the most profound questions in medicine: can we slow, stop, or even reverse aging? (1/4)

"Moderate drinking is heart-healthy" is one of the most repeated claims in cardiology - and it may be a statistical artifact. (1/6)

One number on your CBC may predict 10-year mortality. NHANES, 31,178 adults: severe lymphopenia + high RDW + high CRP → 62% 10-yr mortality in the worst tier. Under 4% in the healthiest. All three already on your CBC. youtube.com/shorts/ogmLU...

On this Memorial Weekend remembering the fallen heroes who fought with my father Clarence R. Lufkin, at Pearl Harbor on the morning of Dec 7, 1941.

Your brain on decades of depression is a snowy mountain carved with deep, well-worn sled tracks. Every thought slides into the same rut. (1/6)

On this Memorial Day weekend, remembering the fallen heroes of the 20th Maine Infantry who fought alongside my great-grandfather, Captain Augustus N. Lufkin, defending Little Round Top at Gettysburg in 1863.

As a medical school professor, I have watched the antioxidant supplement aisle balloon into a multi-billion-dollar industry on a simple story: oxidative stress causes aging, so swallow antioxidants to slow it down. The Cochrane verdict says the opposite. (1/7)

An Army Ranger captain who ran psychedelic retreats for veterans told me the #1 lesson he learned at war AND at McKinsey: Willpower will lose to your environment. Every. Single. Time. (1/3)

It's Never Too Late to Start As a medical school professor, I used to tell patients that the best time to start exercising was 20 years ago. The science says otherwise. (1/6)

Know Exactly When You Stop Ovulating As a medical school professor, I keep coming back to one number women have never had access to: when your ovaries will actually stop. (1/8)

Your Genes Don't Decide How Long You Live As a medical school professor, I taught for years that family history was the dominant signal for longevity. The science has moved on. (1/6)

As a medical school professor, I keep hearing the same story from women in their 40s. (1/7)

He's 91. Injecting young mitochondria into his body. McCully's verdict on mitochondrial transplant: "There is no organ where it has failed." Heart, brain, kidney, lung — every one, repaired. That's not a treatment. That's a clue about aging itself. youtube.com/shorts/70HE2...

As a medical school professor, I am watching a paradox play out in real time. We do not have a health information gap. We have an infobesity epidemic. 10,000 podcasts. 100 hot takes. Zero signal. (1/5)

67 Years Old. 420 Pounds. Off the Floor. As a medical school professor, I was taught that aging is a one-way slide. Muscle melts. Strength fades. You scale back. Then watch this. (1/7)

He's 91 - Won't Wait 20 Years for an Ethics Board As a medical school professor, I've spent decades watching promising therapies stall in regulatory limbo. Then I sat down with John Cramer PhD - the legendary 91-year-old physicist who helped pioneer quantum mechanics interpretations. (1/6)

Insulin Resistance Can Start Reversing in 48 Hours As a medical school professor, I teach that most people think insulin resistance takes months or years to fix. The data say otherwise. Within roughly 48 hours of removing ultra-processed food, the metabolic machinery starts to move: (1/6)

Why a Top UK Surgeon Walked Away From the OR As a medical school professor, I've watched a quiet shift -- some of the best surgeons are choosing prevention over the scalpel. Dr. Mayoni Gooneratne was a leading UK surgeon. Then she walked away from the operating room. (1/5)

John Cramer, PhD, is 91 years old. He told me on Health Longevity Secrets: "In 30 years I'll be 121 — possibly the oldest person on the planet." He's not joking. He's the lab rat in his own mitochondrial experiment. (1/9)

The Kevin Hall NIH 2019 metabolic ward trial is one of the most important nutrition studies of the last decade. Same calories. Same macros. Only difference: ultra-processed vs unprocessed. (1/3)

My home town of Hollywood is finally waking up to the value of metabolic health. What is happening in your community?