Using vDISCO tissue clearing, and a new ultrabright chemical labeling strategy. This work introduces LINCS for rapid, scalable 3D connectivity mapping from single neurons to whole brains, advances for high-throughput circuit mapping. Great work by Rui Lin lab. www.sciencedirect.com/science/arti...

Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf

🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! www.biorxiv.org/content/10.6...

We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

We developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. biorxiv.org/content/10.1...

Excited to share our latest work with Denali Therapeutics as Deep Piction. Using our proprietary clearing & imaging, we’ve mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in both whole mouse bodies and monkey brains. nature.com/articles/s41...

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵 biorxiv.org/content/10.1...

7) 🧩 Main finding 4. Plug-and-play targeting: LipiGo’s DNA handles act as modular building blocks. Conjugating a white adipocyte–specific aptamer enabled tissue-specific mRNA delivery with enhanced uptake in white adipocytes 🎯

See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...

I have this afternoon put Lancashire’s games at Southport and Blackpool in my diary.

States across the South are redrawing congressional maps after the Supreme Court's effective gutting of the Voting Rights Act, says @ariberman.bsky.social of Mother Jones. “This could lead to the largest drop in Black representation since the Jim Crow era, and it is happening with alarming speed."

Anthony Edwards has been ruled out for the rest of Game 4 with a left knee injury, Timberwolves say. Another tough blow for Minnesota after losing Donte DiVincenzo to a right lower leg injury earlier in the game. DiVincenzo left the arena in a wheelchair.

Wasps are crucial for ecosystems! We NEED them, and if you take a second to look at them, you may realize there's a lot more to them than you've thought #wasp #hymenoptera #science #entomology #biology #bees #nature #wildlife #photography #texas

Happy New Year! We're grateful for our community's support as we work together to end homelessness. This year, let's continue to build a stronger Central Ohio for all. CSB is closed Jan. 1-2. We'll be back Jan. 5. Call the Homeless Hotline at 614-274-7000, open 24/7, for help.

It’s tussock moth caterpillar season again! And in its honor I’m reposting this video from 2024 about “the chunks” aka the horrible rash that they cause. Lol trust me, you don’t want the chunks! #forest #nature #outdoor #outdoors #wild #forester #animal #animals #wildlife #insect #insects #woods

Bloomington Illinois representing at today’s No Kings!

A week ago, Jerry left Ben & Jerry's. Thanks to everyone who has sent their support. Keep sharing to get the word out and #FreeBenAndJerrys!

Eight 100% pure essential Wellness Oils with Jojoba Oil that is great for their potential health benefits, improving mood, reducing stress, promotes wellness, clear negative thoughts, calmness & stability, and so much more. meltsbysusanstore.etsy.com ebay.com/str/susancan...

"I didn’t know about the earliest origin of Memorial Day until I was a grown-ass man, and it’s because some folks didn’t want us to." - @cwebbonline.com

❗️A 🇺🇦Ukrainian fighter jet, using a high-precision aerial bomb, destroys 🇷🇺Russian positions along with a field ammunition depot

President Trump's "Biggly Wiggly" plans over the weekend prevented him from attending Junior's wedding. Just too busy being scattered, I guess! 😂😂😂 FOLLOW ME & SUBSCRIBE: KnockOnNews.Substack.com - a satire. Time to Impeach: #OccupyDemocrats #PoliticalSatire #TheResistance #pdamerica #Politics

Don't mind me, just using my Explore Kit AJ & Lulu are streaming on #youtubegaming & #twitch every Thursday at 7pm PST! #streamer #gaymer #queer #youtube #indiegaming #lgbt #anime #pokemon #retro #pixelgames #rpgmaker #pokopia #cozygaming #cozygames #retrogaming #pokemonecho #fangame

Speier's two strikeout pitches

Full answer from Dan here, video via the Mariners

and that's on smoove butta rhythms⚡️ #boombapbeats #boombap #beats

Liverpool welcome back two returning players to the squad, but lose another one, while it's all change for Chelsea in personnel and formation. #lfc #liverpool #chelsea #premierleague #teamnews

Reports indicate Israeli forces set fire to displaced Palestinians' homes in Jabalia camp. #Israel https://osint-signals.com/summary/757

Tommaso Ciampa finding out the hard way you empty the can before you look for plunder as it is ANYTHING GOES between Ciampa and Mark Briscoe! #AEWDynamite is LIVE on TBS and HBO Max

Dance Before We Walk. One of my fav scenes. Movie The Idea of You. #nicholasgalitzine

2025 was a year that tested science's place in the world. International Science Council's CEO, Salvatore Aricò, reflects on the year's achievements and the responsibilities of science in a changing world.

GP practices are patient data protectors The new Health Bill will remove the GP & move the data controller (protector) role to the Secretary of State for Health Your sharing data ‘opt-out’ may not be protected in the same way I have ‘opted out’ but doesn’t stop sharing data

Crazy assholes! — this is how President Zelenskyy commented on yesterday's russian attack on Kyiv and the region.

Taking care of yourself is not a luxury; it's a necessity. Your well-being matters whether you're a family member or a professional caregiver. FND shares simple, practical ways to manage stress, care for your health, and prevent burnout. #Caregiver #Wellness #SupportForCaregivers #ParentSupport

Your donation is an investment in the future leaders of our community." ​"Help us empower these children through education and skill-building." ​"We are focused on unlocking the potential within every child." ​"Support their growth toward self-reliance."

Film: Big Eyes (2014) [PG-13] Studio: The Weinstein Company Character: Dee-Ann Actor: Krysten Ritter Director: Tim Burton Screenwriters: Scott Alexander & Larry Karaszewski Timestamp: 0:58:05 cinematicfbombs.com/2025/04/21/2...

the insanity continues. fk the left. @mattvanswol Meet Jena Salem, a physician in DeKalb County GA. A man with over 40 PREVIOUS CHARGES cut her electricity, jumped on her bed, strangled her, slit her throat, st*bbed her in the chest, and then se*ually assaulted her.

New Mexicans deserve a senator that will fight for them! Did you know there's a list of 21 bills with over 80% approval nationally, that STILL haven't been passed? This is absolutely shameful! #TooPissedOffToBeBoughtOff #MattDodsonforUSSenate #WorkersOverBillionaires #VoteNewMexico

3 time Trump voter, Amanda Robbins calls him a “worthless piece of shit,” for gas prices skyrocketing. We get it Amanda #UnderTrumpGasStinks glad you have come to your senses and realize he sold everyone a bunch of malarkey.

The world’s silence over Spanish police treatment of Gaza flotilla “activists” is deafening.

Mais #Jimin por aqui porque... 🖤💙 #BTS 💜

Stronger immunity starts from within 💪🍊✨ These liposomal Vitamin C capsules are designed for better absorption—helping support your immune system, skin health, and daily energy the smart way. More absorption. More benefits. Every day.

👀 14 pounds in one year. Onlookers are dissecting the newly released White House medical memo on the President’s health. #WalterReed #DonaldTrump

"Instead of investigating, DOJ, FBI ignored it. When Trump returned to office, there'd been no federal investigation to determine what happened to voting system software, how far it was shared, where it is now. That same software is still in use in many states across the country, counting votes."

WEMBY STEP-BACK THREE 😱 (via @NBA) Original post

MTA8 America United Kingdom (UK) #MTA8America #UnitedKingdom

The Blue Jays take the lead on a Vladimir Guerrero 2-run home run! Guerrero Jr. SLG on elevated pitches 2023: .391 2024: .500 2025: .636 (!) #WorldSeries

Sometimes, breaking through means picking up old tools… 🧰 If you’re struggling with the work you’re doing today, take a break & practice something you’re already great at. 💪 It’ll help remind you of what the hard thing you’re doing can feel like once you master it. #Stoicism #Strategy

January has been anything but dry, and Ardingly Reservoir is now full. Yet Mid Sussex residents are still under a hosepipe ban. Please sign my petition calling for the hosepipe ban to be lifted. South East Water need to lift the ban now! www.midsussexlibdems.org.uk/campaigns/en...

Done! Das war ein mehr als erfolgreicher Launch, mit den üblichen kleineren Bugs, die nächste Woche aber gefixt werden können und keine Einflüsse auf die Funktionalitäten für die Kunden haben sollten. Sehr stolz auf das Team, welches das Ding vom Konzept zur Realität begleitet und getrieben hat.

If it’s starting to feel uncomfortable, slipping down, or leaking… your body is probably telling you it’s time for a change. And even if it’s not full, don’t keep a tampon in for too long. Tampons should generally be changed every 4–8 hours to avoid developing Toxic Shock Syndrome (TSS).

The one and only: Derrick White 👏

I’m happy to clarify. President Clinton brought up a conversation he had with Trump in NYC re: Epstein. President Clinton said that Trump told him that he had a falling out with Epstein due to a land dispute. This directly refutes Trump’s claims about why he fell out with Epstein.

📺 Els titulars més destacats d'aquest diumenge 31 de maig de la mà de Laura Mesa i Albert Font | @rtvecatalunya.bsky.social ➕ Notícies a rtve.cat

Proud to be part of the movement #HandsOff2025

Η #Ελληνίδα #ιπτάμενη #πιανίστρια στο πιο #μυστηριώδες #μοναστήρι της #Ευρώπης The #Greek #flying #pianist in the most #mysterious #monastery in #Europe #τέχνη #μουσική #Ελλάδα #art #music #Greece #πιάνο #piano

#delaneyhall

La Chine a fourni à l'Iran un radar JY-27A, censé détecter les avions de chasse furtifs. L'Iran l'a déployé sur l'île de Goruk & ce radar a été détruit par un avion de chasse furtif américain F-35. Suite aux nombreuses provocation du régime CGRI, une escalade militaire est possible cette nuit.

YEAH YEAH YEAH YEAH

வரிகள் : கவிஞர் எம்ஏ நுஹ்மான் குரல்: நடிகர்/இயக்குனர் நாசர் யாழ். நூலகம் எரிக்கப்பட்ட 25ஆவது நினைவுநாளின்போது இயக்குனர் @Somee Tharan ஆல் வௌியிடப்பட்ட 'எரியும் நினைவுகள்' ஆவணப்படத்தில் உள்ளடக்கப்பட்டிருந்த காணொளியே இது. #SriLanka #JaffnaLibraryBurning #JaffnaLibrary