We discovered that the skull bone marrow has direct connections to the brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies. Kolabas…Ertürk, Cell (2023): www.cell.com/cell/pdf/S00... Our Tech: www.biorxiv.org/content/10.1... bit.ly/3PQuymm

7) 🧩 Main finding 4. Plug-and-play targeting: LipiGo’s DNA handles act as modular building blocks. Conjugating a white adipocyte–specific aptamer enabled tissue-specific mRNA delivery with enhanced uptake in white adipocytes 🎯

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

To see how obesity affects the body, we used vDISCO clearing and imaging to visualize the peripheral nervous system in both lean and obese mice.

We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

Additionally, we visualized infiltrating CD68-EGFP immune cells linked to chronic inflammation in obesity on the whole-body scale.

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf

Using vDISCO tissue clearing, and a new ultrabright chemical labeling strategy. This work introduces LINCS for rapid, scalable 3D connectivity mapping from single neurons to whole brains, advances for high-throughput circuit mapping. Great work by Rui Lin lab. www.sciencedirect.com/science/arti...

4 ➡️ Main finding 1. DNA handles protruding from LipiGo enabled functional liver detargeting and strong spleen accumulation. Unlike conventional LNPs that mainly go to the liver, LipiGo redirects mRNA delivery to lymphoid organs.

See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...

J.K. Rowling's business secret is so simple that noone does it. To watch full video go here: https://youtu.be/c8yqS8kCjIk

A fitting sendoff for Stephen Colbert from his friend Jon Stewart with a surprise appearance from the great Andra Day – inspiring us all to Rise Up.

This is beautiful. 🥹 Statistically, there is a higher concentration of LGBT community members in rural areas than there are in urban. Paint a rainbow today to support an entire community. Sending ❤️ to all the 🌈s today. Keep showing up!! #Rainbow #Pride #RainbowConnection Credit: @thekristinkey

If you live in or near Caldwell Idaho, can you please watch this. 🙏 This mom is trying to orchestrate a birthday parade for her 6 year old son’s birthday. 🎂

The great @thinkingbasketball.bsky.social pointed out in the members only video below how adept Dylan Harper is at adjusting to avoid the shot blocker and finishing at the rim as he showed in the first quarter of game one here.

just putting the last touches on this kings head crock. finished it off with a line of "the diggers song", a rhyme popular among the followers of the "true levelers" or diggers movement during the english civil war of the mid 17th century #pottery #folkart #History #skull #kingshead

Ich schwöre sonst bin ich viel besser🤣 #gaming #Fortnite #germangirl🇩🇪 #KathyClips #BattleRoyale #viral #randomsquad

❗️[ 🇧🇴 BOLIVIE ] 🔸 Un groupe indigène armé à Chayanta, dans la région de Potosí, annonce se préparer à la guerre et exige la démission de Rodrigo Paz, ses membres étant notamment équipés de fusils Mauser M1933 et M1907.

💰 J6 Financial (Daily Show) @thedailyshow.com

January 6 was a constitutional crisis that continues. The mob stopped the count, terrorized Congress, and left one dangerous question behind. Who paid for it? Listen: https://loom.ly/REdODrI #oligarchy #dictatorship #dictatortrump

Don’t let St. Patrick’s Day sneak up on you 🍀 ✨ BUY 3, PAY FOR 2 🚚 Free shipping ⚡ Free 2–4 Day FedEx $115+ If you want it before the day… Order now. Trust me — the last-minute panic is not fun. #StPatricksDay #IrishBracelet #IrishAmerican #Buy3Pay2 #HandmadeInIreland #SupportSmall

LET’S TALK RECORDS! No. 90 (Redux): LET IT BE by THE REPLACEMENTS Part 2 #letstalkrecords #thereplacements #letitbe #collegerock #punk #punkrock #alternative #alternativerock #vinyl #vinylcollection #vinylcollector #vinylcommunity #vinylrecords #music

Came so close to another naneinf but ran out of runway. Frustrating to fail when you’re just a few hands away. Had money problems the whole time. But not a bad score in the end. I’ll take 8.406e241 any day.

Stage view of Ospreay at the end of his match vs Joe @claudiatakesoup.bsky.social #AEW

Some MPs say that the UK is doing enough on climate change. The experts disagree. Here, leading extreme weather expert & member of the Climate Change Committee, Prof @hayleyjfowler.bsky.social. Please share with your MP. Full talks: www.nebriefing.org #NEB2025 #TimeToStepUp

We’re replaying one of our most special podcast series of EdUp Canada Podcast, Sea of Opportunities ⚓ Today, we’re sharing this episode where Michael Sangster speaks with a Royal Canadian Navy leader about an unexpected career pivot, life aboard HMCS St. John’s. 🔊 Listen now: buff.ly/eOVdV6R

It never works out for Trumpholes when they get in my face to talk shit! #DealingWithTrumpholes

Artemis II splashed down off the San Diego coast, drawing crowds across the region. Ryan Thompson reports from the San Diego Air & Space Museum, where people gathered to watch the historic return.

CRIME CONSPIRACY, A BUCK TAYLOR NOVEL BY CHUCK MORGAN Conspiracies, dermestid beetles, infrasound weapons, and a Cold War bunker ⭐⭐⭐⭐⭐ “Crime Conspiracy bristles with red herrings and pesky evidence rules that are true-to-life, and I had a grand time reading it.” Reader’s Favorite Review.…

I made a fren at the grocery store! Zelephina 🥰

Endymion Ball Finale Katy Perry performs. 2nd clip

I know this is about Freddie Gibbs, but what Jay Electronica did for the MEME space this year is unmatched.

🥺

Trump administration is repealing a rule that prevents power plants from releasing hundreds of millions of gallons of toxic mercury and arsenic into drinking water because fuck you that's why.

✈️ 𝐓𝐢𝐤𝐓𝐨𝐤𝐞𝐫'𝐬 𝐕𝐢𝐫𝐚𝐥 𝐏𝐥𝐚𝐧 𝐭𝐨 𝐁𝐮𝐲 𝐒𝐩𝐢𝐫𝐢𝐭 𝐀𝐢𝐫𝐥𝐢𝐧𝐞𝐬 - 𝐄𝐩. 178 #𝐬𝐩𝐢𝐫𝐢𝐭𝐚𝐢𝐫𝐥𝐢𝐧𝐞𝐬 #𝐭𝐢𝐤𝐭𝐨𝐤 #𝐯𝐢𝐫𝐚𝐥𝐯𝐢𝐝𝐞𝐨 Like this post and want to support independent journalism? You can help! Like it 👍 Share it 👆 Follow me 👉 Subscribe 🤘 to The Business Behind The News #business #businessnews #tbbtn #youtube #shorts

NASA’s Fermi Glimpses Power Source of Supercharged Supernovae youtu.be/Oq9C7XTrFxk science.nasa.gov/missions/fer... Researchers say it likely received its power-up from a supermagnetized neutron star born in the stellar collapse that triggered the explosion

“If I couldn’t accept curfew, how could I accept this? … I couldn’t, I can’t accept it. It’s worse.”

Trump Admires And Asks Staff To Photograph Column Outside The Whitehouse

Thank you, Maricella! 💙 @beachblond52.bsky.social @kelofchgo.bsky.social @allie10.bsky.social @kimandmickysmith.bsky.social @sam--2025.bsky.social @suzala.bsky.social @colette73.bsky.social @lyndapole.bsky.social @bluestormcomin1.bsky.social @raykwong.lol

"Republicans know this is a loser." Joel Payne and @stephruhle.bsky.social dig into the politics of the Iran war on the #Nightcap after Pete Hegseth faced some tough questions from both Democrats and Republicans on Capitol Hill.

Consumer News: March 12, 2026 Mortgage rates make a big jump up. Congress is looking to make homes more affordable. Plus, oil is back over $100 per barrel. #MortgageRates #homeownership #oil

HEINE HEINE HEINE HEINE HEINE HEINE HEINE HEINE MAN

Morning. #AFC #MCFC 😭😭😭😭😭😭😭

Big promises, new packaging. The White House’s “Great Healthcare Plan” targets drug prices, subsidies, and transparency. But history shows reforms like this can shift costs as much as they reduce them. The fine print matters. @sonyasloanmd.bsky.social @drhaydeebrown.bsky.social @meidastouch.com

I wrote about Kam Jones, as a primary ball-handler, with his quirks & rhythms presented via a single sequence: - "get" action to get back left - reject screen to his right w/ R-L cross - spin over right shoulder for lefty floater On running point - up to a point: www.patreon.com/posts/kam-jo...

Listen to their words. #FreePalestine

We love that our players can discover our games everywhere, but please don't try to beat your score with the moonerang while driving...#SeaofStars

This post has no hashtags… if it reaches you, you're a true Turn-Based Tactics fan! 💥

The other day Jessica Denson, Cliff Cash, and Carlos Alvarez. #wethepeople #protest #arresttrump #removetrump #arrestmusk

it was already pretty fucking gay in the ED

NASA’s Roman Space Telescope Primary Mirror Gets Last Look www.youtube.com/watch?v=fAgr... www.nasa.gov/missions/rom...

For America 250 we could have had Taylor Swift, Bruce Springsteen, Lady Gaga, Beyoncé, and others preform for our nation’s birthday if we had a Democrat in office. Now Trump is having even D-list celebrities cancel on him because he is turning the event into a party for and about himself.

Edmuuuuundooooo

"During a protest, an Israeli reporter tried to question a young Jerusalemite woman, asking dismissively, “Aren’t we all Israelis?” With absolute confidence and calm that speaks volumes, the young woman replied: “Not me.. I am Palestinian.”(Pal Global echo) #Israel

This will be an ambitious budget framed by an ambitious government, in difficult and uncertain times.

The PA Senate GOP Majority explaining away why they don’t stand with working Pennsylvanians.

🔨 🪜 We're building something new...launching May 12th! 🪛 🚧

Over the past four years, the Ukrainian people have fought heroically to defend their home against Russia’s unprovoked invasion. Now, Trump is letting Putin rake in billions of dollars to fuel his war of conquest. Here’s how:

.@HeymanHustle is feeling this one today 😅 @bronbreakkerwwe

Los del ICE se llevan a gente que se está graduando!!